2024 Adipose tissue at single-cell resolution

Adipose tissue at single-cell resolution

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August undefined, 2024

Webadipose cell, also called adipocyte or fat cell, connective-tissue cell specialized to synthesize and contain large globules of fat. There are two types of adipose cells: white … WebOct 23, 2024 · Adipose tissue plays an important role in the maintenance of energy balance in mammals. A chronic imbalance between energy intake and expenditure increases adiposity and leads to obesity and predisposes to the development of metabolic disease (Rosen and Spiegelman, 2014; Wajchenberg, 2000).White adipose tissue …

Microarrays Free Full-Text Evaluating the Effect of Cell Culture …

WebFeb 15, 2024 · Adipose tissue is highly heterogeneous and plastic. Recent advances in single-cell/nucleus RNA sequencing technology have helped to study the cellular composition and dynamics of adipose tissue. In this protocol, I outline a typical workflow of analyzing single-cell/nucleus transcriptome data. WebDec 16, 2024 · Single-cell mapping of human and mouse white adipose tissue across different depots and body masses revealed cellular heterogeneity, and identified distinct subpopulations of adipocytes,... rwbyf news

Single cell type - EIF2B5 - The Human Protein Atlas

Webadipose tissue at a single-cell resolution and provide an extensive resource for future insights in how to target obesity.1 Obesity, characterized by excessive amounts of adipose tissue, is a condi-tion associated with elevated risk of developing metabolic diseases including cardiovascular disease, type 2diabetes,andnon-alcoholicsteatohe- Webadipose tissue, or fatty tissue, connective tissue consisting mainly of fat cells (adipose cells, or adipocytes), specialized to synthesize and contain large globules of fat, within a structural network of fibres. It is found … WebHere we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify … is days gone co-op

Isolation of Adipose Tissue Nuclei for Single-Cell Genomic …

Can we target obesity using a single-cell atlas of adipose …

WebMar 7, 2024 · Adipose tissues are loose connective tissues with a high number of adipocytes. These specialized cells store metabolic energy in the form of large cytoplasmic lipid droplets and at the same time regulate several aspects of organismal physiology … WebOct 29, 2024 · Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. About. Single-cell analysis of human adipose tissue Resources. Readme License. MIT license Stars. 0 stars Watchers. 1 watching Forks. 0 forks Report repository Releases No releases published. Packages 0. No packages published . rwbyf outstanding sharesWebTwo clusters of mature adipocytes, identified through single nuclei RNA sequencing (snRNA-seq), were distinctive for proinflammatory/immune or metabolic gene expression patterns that became more transcriptionally diverse in adult animals. is days gone free

"WebApr 3, 2024 · Fat grafting is one example of an autologous technique where autologous adipose tissue (isolated from a donor site via liposuction) is injected into the breast. However, it lacks structural support and vasculature, which results overtime in a stress-induced volume loss of 20%–70% due to the applied forces (Visscher et al., 2024), … " - Adipose tissue at single-cell resolution

Adipose tissue at single-cell resolution

Adipose-derived stem cells promote the repair of chemotherapy …

Websingle cell type. showing cell type specific rna data of eif2b5 (eif-2b, eif2bepsilon). ... single cell type adipose tissue. adipose tissue bone marrow brain breast bronchus colon endometrium esophagus eye heart muscle. kidney liver lung lymph node ovary pancreas pbmc placenta prostate rectum. WebMay 13, 2024 · Adipose tissue is a multicellular tissue with depot-dependent functions including safe energy storage and release, immune defense, thermogenesis, and organ padding. Emont et al. zoom in on white adipose tissue at a single-cell resolution and provide an extensive resource for future insights in how to target obesity.

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WebMar 25, 2024 · Human adipose tissue cells were isolated using a previously described protocol, under ethics protocol number 2012-1308 approved by the CRCHU-de Québec-Université Laval ethics committee. Adipose-derived stem/stromal cells (ASCs) were thawed and amplified in culture according to previous studies. [ 38 ] WebOct 28, 2024 · Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite) 1. It is an important regulator of systemic metabolism, as shown by …

WebJul 18, 2024 · Here we examine an established population of human adipose-derived stem cells (ASCs) using a novel, microfluidic-based method for high-throughput transcriptional interrogation, coupled with advanced bioinformatic analysis, to evaluate the dynamics of single cell gene expression among primary, passage 0, and passage 1 stem cells. WebJun 6, 2024 · The ultimate goal of this protocol is to determine all adipose tissue subtypes under various thermogenic stimuli at a single-cell resolution. In contrast to other …

WebApr 27, 2024 · Human adipose tissue was isolated from healthy patients (patient information in Supplementary Table 1 ), dissociated into single-cell suspensions, sorted … WebAdipose tissues display a remarkable ability to adapt to the dietary status. Here, we have applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose tissue at single-nucleus resolution in response to high-fat-diet-induced obesity.

WebApr 12, 2024 · Adipose tissue is a specialized connective tissue consisting of lipid-rich cells called adipocytes. As it comprises about 20-25% of total body weight in healthy individuals, the main function of adipose tissue is to store energy in the form of lipids (fat).

WebFeb 27, 2024 · Highlights Multidimensional transcriptome analysis at single-nucleus resolution recovers nuclei of cell types in adipose tissue Adaptative thermogenic response results in 3 distinct mature adipose cell types Single-nuclei transcriptomic-based secretome analysis reveals adipose cell-type-specific genes rwbyf stock forumWebMar 7, 2024 · Summary. Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological … is days gone funWebJun 6, 2024 · The ultimate goal of this protocol is to determine all adipose tissue subtypes under various thermogenic stimuli at a single-cell resolution. In contrast to other tissues and cell types, determining cellular subtypes of adipose tissue is challenging due to the fragility of lipid-filled adipocytes. is days gone offlineWebMar 7, 2024 · Adipose tissue at single-cell resolution Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under … is days gone free on ps4WebMarch 22, 2024 - 110 likes, 1 comments - Nutrition In Sync (@nutritioninsync_rc) on Instagram: "Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabol ... rwbyteaddressbuffer hlslWebFrom Better Models to Single-Cell Resolution to Study Adipose Tissue In the absence of functional adipose tissue, lipids accumulate in peripheral organs, such as the liver, … rwbyf stock forecastWebAdipose tissues display a remarkable ability to adapt to the dietary status. Here, we have applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white … rwbypedia