WebSimvastatin interaction with clarithromycin and amiodarone causing myositis. Ann Pharmacother. 2005 Oct;39 (10):1760-1. doi: 10.1345/aph.1G195. Epub 2005 Sep 13. WebApr 27, 2024 · An event is serious (based on the ICH definition) when the patient outcome is:Drug interaction. An 81-year-old man developed rhabdomyolysis and drug-induced liver injury (DILI) following concomitant administration of simvastatin and clarithromycin. The man was admitted to the ED due to asthenia, muscle weakness …
Clarithromycin/simvastatin interaction SpringerLink
WebMar 14, 2024 · Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor. It has previously been shown to cause rhabdomyolysis in patients taking simvastatin . AKI is a serious complication of rhabdomyolysis and a recent case described a patient requiring haemodialysis for statin-induced-rhabdomyolysis after being prescribed clarithromycin . … WebApr 27, 2024 · An 81-year-old man developed rhabdomyolysis and drug-induced liver injury (DILI) following concomitant administration of simvastatin and clarithromycin. The man … guthrum ks2
clarithromycin oral and simvastatin oral Drug Interactions
WebDiscussion: Clarithromycin is a potent inhibitor of CYP3A4, the major enzyme responsible for simvastatin metabolism. The concomitant administration of macrolide … WebApr 10, 2024 · Rhabdomyolysis is a potentially life-threatening disease caused by melting or necrosis of skeletal muscle cells and leakage of muscle components into the bloodstream. It has been reported that the interaction of the HMG-CoA reductase inhibitor rosuvastatin with the renal anemia drug vadadustat increases the blood concentration of rosuvastatin in vitro. WebJan 14, 2013 · Drug interaction. An 88-year-old woman, who had a history of ischaemic heart disease, hypertension and arrhythmia, developed rhabdomyolysis whilst receiving … box support hold its