Did you know?
WebJan 31, 2012 · Furthermore, Dlgh1 silencing abrogated Treg function, impaired NFATc1 activation, reduced phosphatase and tensin homolog levels, and increased Akt activation. Dlgh1 operates independently of the negative feedback pathway mediated by the related adapter protein Carma1 and thus presents an array of unique targets to selectively … WebJun 30, 2010 · The Drosophila 'discs large' tumor suppressor protein, Dlg, is the prototype of a family of proteins termed MAGUKs (membrane-associated guanylate kinase …
WebGene: Dlg1 MGI:107231 Not currently registered for phenotyping at IMPC Phenotyping is currently not planned for a knockout strain of this gene. Gene Summary Name: discs large MAGUK scaffold protein 1 Synonyms: B130052P05Rik, SAP97, Dlgh1 Order Alleles IMPC Data Collections No Body Weight Data No Embryo Imaging Data No Viability Data WebJan 9, 2012 · DLGH1, a mammalian homologue of the Drosophila tumour suppressor Discs large 1, is expressed in all the different types of epithelia present in the human uterine cervix and localizes primarily to the basal …
WebMay 1, 2007 · Abnormal urogenital organs in prenatal Dlgh1-/-mice at E18.5. (A,D-F) Urinary organs of male Dlgh1 +/+ (A), and male (D) or female (E,F) Dlgh1-/-mice. (D) … WebDlg1 Name discs large MAGUK scaffold protein 1 Synonyms B130052P05Rik, Dlgh1, SAP97 Feature Type protein coding gene IDs MGI:107231 NCBI Gene: 13383 Alliance gene page Transcription Start Sites 21 TSS Location & Maps more Sequence Map Chr16:31482261-31692174 bp, + strand From NCBI annotation of GRCm39 Genetic …
WebDlgh1 contains no transmembrane domain or putative sites for lipid modification that would allow it to associate with the plasma membrane or the lipid raft compartment (28). Figure 2. Dlgh1 specifically associates with the Lck SH3 domain, and this interaction is required for Dlgh1 association with detergent-
Web3 beds, 2 baths, 1710 sq. ft. house located at 4001 Glenheath Dr, Dayton, OH 45440 sold for $53,000 on Dec 22, 1978. View sales history, tax history, home value estimates, and … healthcare fundraising consultantsWebDec 26, 2006 · Discs-large homolog 1 (DLGH1) is a mouse ortholog of the Drosophila discs-large (DLG) tumor suppressor protein, a founding member of the PDZ and MAGUK protein families. DLG proteins play important roles in regulating cell proliferation, epithelial cell polarity, and synapse formation and function. healthcare fundsWebDMD is a lethal genetic disease of childhood, caused by mutations in DMD, which encodes the dystrophin protein. Without functional dystrophin, defects in sarcolemma stabilization lead to progressive muscle damage, while inherent stem cell … healthcare fundraising trainingWebFeb 7, 2005 · Dlgh1, the mouse homologue of the human hDlg and rat SAP97, is a member of the membrane-associated guanylate kinase protein family (MAGUK). MAGUKs are … health care funds in australiaWebIn the mammalian embryo, DLGH1 is essential for normal urogenital morphogenesis and the development of skeletal and epithelial structures. Recent reports also indicate that … golf turf mat nzWebDec 24, 2006 · Dlgh1 contains multiple protein-interaction domains and therefore identification of Dlgh1-interacting proteins in T cells is essential … healthcare funds performanceWebDlgh1 is a member of the membrane-associated guanylate kinase (MAGUK) family of molecular scaffolds, which organize signaling complexes in neuronal synapses. Dlgh1 participates in actin-dependent TCR and lipid raft clustering, NFAT activity, and cytokine production. Upon engagement of TCR and CD28 Dlgh1 associates with the SH3 domain … healthcare funds for people