2024 Glycogen accumulation and phase separation

Glycogen accumulation and phase separation

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August undefined, 2024

WebPhase separation is an emerging paradigm for understanding the biochemical interactions between proteins, DNA, and RNA. Research over the past decade has provided … WebGlycogen accumulation and phase separation drives liver tumor initiation. Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6PC) catalyzing the last ...

Glycogen accumulation and phase separation drives liver tumor ...

WebGlycogen accumulation and phase separation drives liver tumor initiation. Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, … WebGlycogen accumulation and phase separation drives liver tumor initiation. Author links open overlay panel Qingxu Liu 1 7, Jiaxin Li 1 7, Weiji Zhang 1 7, Chen Xiao 1 7, Shihao Zhang 1 7, Cheng Nian 1, Junhong Li 1, Dongxue Su 1, Lihong Chen 2, Qian Zhao 3, Hui Shao 4, Hao Zhao 1, Qinghua Chen 1, Yuxi Li 1, Jing Geng 1, Lixin Hong 1, Shuhai Lin ... mark horsley orthopaedic surgeon

Glycogen accumulation and phase separation drives liver tumor ...

WebConsistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, we concluded that cancer-initiating cells adapt a glycogen storing mode, which blocks Hippo signaling through glycogen phase separation to augment tumor incidence. WebJan 3, 2024 · The accumulation of protein aggregates is often harmful and even lethal to cells and has been reported to be associated with several human diseases, such as neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and prion disease [7]. ... pyroptosis, and ferroptosis. Phase separation is an idea drawn from the … WebDec 2, 2024 · Glycogen serves as a mobilized storage form of glucose predominantly found in the liver and skeletal muscle but also in the brain, heart, kidney, adipose tissue, … navy blue dress shoes for little girls

Glycogen accumulation and phase separation drives liver

WebOct 21, 2024 · Europe PMC is an archive of life sciences journal literature. WebNov 2, 2024 · Glycogen accumulation is a key carcinogenic event in the malignant transformation of the liver [8]. ... which blocks Hippo signaling through glycogen phase … mark horstman pebble beach californiaWebGlycogen is a glucose polysaccharide occurring in most mammalian and nonmammalian cells, in microorganisms, and even in some plants. It is an important and quickly mobilized source of stored glucose. In vertebrates it is stored mainly in the liver as a reserve of glucose for other tissues. In hepatocyte cells it is accumulated and mobilized ... mark horstman manager tools

"WebPublications related to biomolecular condensates, phase separation, llps and more. Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6PC) … " - Glycogen accumulation and phase separation

Glycogen accumulation and phase separation

WebOct 29, 2024 · Glycogen accumulation and phase separation drives liver tumor initiation through blocking Hippo signaling. A research paper based on the results titled … WebOct 27, 2024 · Glycogen accumulation and turnover were also required for long-term cold adaptation in these models. Both synthetic and degrading enzymes are coordinately increased by β-adrenergic activation and ...

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WebMay 13, 2024 · Glycogen is a polysaccharide that comprises α-1,4-linked glucose backbone and α-1,6-linked glucose polymers at the branching points. It is widely found in organisms ranging from bacteria to eukaryotes. The physiological role of glycogen is not confined to being an energy reservoir and carbon source but varies depending on organisms. … WebJul 8, 2024 · Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. ... f Glycogen accumulation and phase separation lead to ...

WebApr 11, 2024 · The number of people living with chronic kidney disease (CKD) is growing as our global population continues to expand. With aging, diabetes, and cardiovascular disease being major harbingers of kidney disease, the number of people diagnosed with diabetic kidney disease (DKD) has grown concurrently. Poor clinical outcomes in DKD could be … WebJan 15, 2014 · recommendation: In the absence of any treatment-related changes within a study, the degrees of glycogen demonstrated in Figure 1, Figure 2, and Figure 3 are considered background (spontaneous) …

WebGlycogen accumulation and phase separation drives liver tumor initiation. Journal content Created on Oct 21, 2024 by Cell. ... in Disciplines. Published in. Cell, Cell Press (Reed … WebOct 26, 2024 · Glycogen accumulation and phase separation drives liver tumor initiation through blocking Hippo signaling. A research paper based on the results titled “Glycogen accumulation and phase separation drives liver tumor initiation” was published on the Cell website on 21 October 2024. Co-first authors of the paper are PhD students including Liu ...

WebOct 21, 2024 · Glycogen Accumulation and Phase Separation Drives Liver Tumor Initiation. Scientists reported that glycogen accumulation was a key initiating oncogenic event during liver malignant transformation, and found that glucose-6-phosphatase catalyzing the last step of glycogenolysis was frequently downregulated to augment …

WebSep 5, 2024 · Furthermore, additional studies identified novel roles of nuclear glycogenolysis as a supply of acetyl-CoA for epigenetic modulation (Sun et al, 2024), storage of glycogen in brown adipose fat mediated by gut microbiota (Li et al, 2024), and glycogen accumulation in liver cancer aiding in liquid–liquid phase separation fueling … markhor shipping line llcWebOct 21, 2024 · Europe PMC is an archive of life sciences journal literature. navy blue dress shoes for women size 10WebNov 30, 2024 · Liu, Q. et al. Glycogen accumulation and phase separation drives liver tumor initiation. Cell 184 , 5559–5576 (2024) Article CAS Google Scholar navy blue dress socks womenWebOct 28, 2024 · Glycogen accumulation induces glycogen-Mst1/2 aggregate foci in cells, related to Figure 3 (A and B) Immunofluorescent staining of Mst1 (red) and DAPI ... mark horstman pebble beachWebGlycogen storage disease type 1 (GSD1) is an inherited disorder caused by impaired glucose 6-phosphatase activity. ... levels in the postabsorptive phase and upon fasting. The G6Pase complex is composed of 2 subunits, that is, a catalytic ... hepatocytes are chronically stressed due to abnormal glycogen and lipid accumulation, which induce ... mark horstmann heightWebGlycogen accumulation and phase separation drives liver tumor initiation Qingxu Liu, Jiaxin Li, Weiji Zhang, Chen Xiao, Shihao Zhang, Cheng Nian, Junhong Li, Dongxue Su, … mark horstman obituaryWebGlycogen accumulation and phase separation drives liver tumor initiation. Journal content Created on Oct 21, 2024 by Cell. ... in Disciplines. Published in. Cell, Cell Press (Reed Elsevier) Content. Accumulated glycogen undergoes liquid-liquid phase separation to suppress Hippo signaling and drive liver tumor initiation. Qingxu Liu, Jiaxin Li ... navy blue dress shorts