2024 Jph2 molecular weight

Jph2 molecular weight

Author: snov

August undefined, 2024

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic membrane occupa… NettetJPH2 Junctophilin-2: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. ... Molecular weight: 74,259 Da

JPH2 protein expression summary - The Human Protein Atlas

Nettet30. mar. 2024 · ( G) mRNA expression levels for JPH2 and CAV3. ( H) Protein expression levels determined using JPH2 (sc-51313, Santa Cruz Biotechnology) and CAV3 (ab2912, Abcam) antibodies. n = 5 per group for G and H. * P < 0.05 and ** P < 0.01 vs. the euthermic group by Student’s t test. Open in viewer Increased Expression of JPH2 and … Nettet18. apr. 2007 · Junctophilin-2 (JPH2) is a cardiac specific member of the junctophilins, a newly characterized family of junctional membrane complex proteins important in physically approximating the plasmalemmal L-type calcium channel and the sarcoplasmic reticulum ryanodine receptor for calcium-induced calcium release. cold weather payment uc

Analysis of enriched rare variants in JPH2-encoded ... - PubMed

Nettet17. jan. 2003 · HGNC:14202 JPH2 MIM 605267 gene 613873 phenotype 619492 phenotype VEuPathDB HostDB:ENSG00000149596 neXtProt NX_Q9BR39 Subcellular … Nettet24. mar. 2009 · In skeletal muscle, junctophilin-1 (JPH1) is believed to facilitate direct protein-protein interactions between voltage-dependent L-type Ca 2+ channels (LTCC) on the PM and intracellular Ca 2+ release channels (CRCs), specifically the type 1 ryanodine receptor (RyR1), on the SR (36, 40).In cardiac muscle, JPH2 determines the distance … Nettet15. jun. 2014 · JPH2 has emerged as a critical regulator of the complex JMC microenvironment in cardiac myocytes. It provides an anchor for developing T-tubules … cold weather payment working tax credit

Nanoscale coupling of junctophilin-2 and ryanodine receptors

JPH2 Gene - GeneCards JPH2 Protein JPH2 Antibody

NettetExpression of JPH2 protein in cerebral arteries was investigated using the Wes capillary electrophoresis immunoassay system (Fig. 1C). Protein lysates from whole cerebral arteries and hearts... NettetSingle cell type specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The … cold weather payment whenNettetAnti-JP-2 antibody (ab79071) Datasheet SDS Reviews ( 1) Submit a question References (3) Key features and details Rabbit polyclonal to JP-2 Suitable for: ELISA, WB Reacts … cold weather pictures funny

"Nettet9. aug. 2010 · Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. JPH2 is believed to keep the plasma ... " - Jph2 molecular weight

Jph2 molecular weight

Nettet15. des. 2016 · Background: Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 … NettetThe molecular weight distribution (MWD) is conveniently characterized by either the number N(n) or weight W(n) of chains with n repeating units (e.g., a chain with molecular weight M = nm0 with m0 the molar weight of a repeating unit). The normalized functions N — (n) = N(n)/ΣN(n) (1) N — (n) = W(n)/ΣW(n) (2) respectively, are the number ...

Did you know?

Nettet7. okt. 2024 · Protein lysates from whole cerebral arteries and hearts probed with a primary antibody against JPH2 produced bands at the predicted molecular weight of the protein … Nettet7. jan. 2011 · The critical role of this protein in maintaining the precise subsarcolemmal geometry needed for CICR is underscored by the embryonic lethality of JPH2-deficient mice stemming from altered dyadic ultrastructure and stochastic Ca 2+ transients with reduced amplitude. 19 Loss of JPH2 expression was observed in rodent models of …

NettetJPH2 is a hot spot for mutations linked to hypertrophic cardiomyopathy (HCM) ( 15 – 17 ), and repeats in JPH3 have been found to cause Huntington disease-like 2 (HDL-2) ( 18 ). In addition, cardiac stress results in activation of calpain, which cleaves JPH2 and drives heart failure progression ( 19 – 24 ). Nettet9. aug. 2010 · Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes.

NettetView Mouse Monoclonal anti-JPH2 Antibody (OTI1F5) (NBP2-45469). Validated Applications: WB, ICC/IF. Validated Species: Human, Mouse, Rat. Skip to main content ... The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, … Nettet13. aug. 2012 · Several molecular mechanisms have been shown to contribute to downregulation of JPH2 expression levels in failing hearts (28,272). First, the mouse, rat, and human homologues of JPH2 are...

NettetJPH2 has 2,942 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 72 datasets.

NettetJPH2 Junctophilin-2: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. ... Molecular weight: 74,692 Da cold weather payment who gets itNettetJPH2 Protein Molecular Weight & PI The parameters have been computed for the following feature FT CHAIN 1-696 Junctophilin-2. Molecular weight (Da) 74221.56 … dr michelle ho ttshNettetJPH2 Junctophilin-2: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. ... Molecular weight: 74,222 Da cold weather physical readiness trainingNettet20. sep. 2024 · However, the degree of LV hypertrophy may be similar in patients with these founder mutations (22±5 mm, 18±6 mm and 20±5 mm with variant in MYPBC3, … dr michelle howell mandurahNettet1. sep. 2024 · HGNC Approved Gene Symbol: JPH2 Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,106,590-44,187,188 (from NCBI) Gene-Phenotype Relationships PheneGene Graphics TEXT Description dr michelle horn jackson msNettetMethods and Results—JPH2 expression was reduced in flash-frozen human cardiac tissue procured from patients with HCM compared with ostensibly healthy traumatic death victims. Partial silencing of JPH2 expression in HL-1 cells by a small interfering RNA probe targeted to murine JPH2 mRNA (shJPH2) resulted in myocyte hypertrophy and increased cold weather pig breedsNettetTwelve 8-week-old male SD rats with a mean weight of 273.7 ± 3.2 g were randomized into two groups: six rats were subjected to saline (Double Crane Pharmaceutical Co. … dr michelle horvath greensboro