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Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. It catalyzes this formation by removing the 2'-hydroxyl group of the ribose ring of nucleoside diphosphates. This reduction produces deoxyribonucleotides. Deoxyribonucleotides in turn ar… WebAccordingly, two alternative pathways lead either to the inhibition of R1 or R2, for which the 2'-chloro-2'deoxynucleotides serve as the model for the inhibition of R1 and the 2'azido-2'-deoxynucleotides the model for the inhibition of R2. However, the underlying reason for the different behavior of the inhibitors has remained unknown until now. WebDec 1, 2016 · Correction by factoring in inhibitor cross-reactivities significantly improved the correlation (R2=0.736). Conclusions: Correcting in vitro chemical inhibition results for … elderly blood pressure range